Immunoglobulin A, Aflatoxin and the Celiac Screening Test
The Celiac Disease screening test most commonly used is IgA-anti-tTG , and it should be used with an IgA deficiency test, both together. If IgA is high enough, it means the anti-tTG (tissue transglutaminase) test is valid. Yet in some cases it is too low and then an IgG-anti-tTG may be used (again with a check for deficiency in IgG). But what does it mean, in general, if IgA is low? IgA deficiency (or at least functional deficiency) is a possible explanation, for some of the complications of Celiac Disease, including the development of certain cancers like Non-Hodgkin's Lymphoma. The mechanism would be that a lowered IgA leads to chronic immune insufficiency and erratic immune activation. After a period of time, it could lead to a disordered immune response that looks a lot like autoimmune disease. It's so simple, it's almost simplistic. But we must begin at the beginning, at aflatoxins. This post is long and very dense. I...