Immunoglobulin A, Aflatoxin and the Celiac Screening Test
The Celiac Disease screening test most commonly used is IgA-anti-tTG , and it should be used with an IgA deficiency test, both together. If IgA is high enough, it means the anti-tTG (tissue transglutaminase) test is valid. Yet in some cases it is too low and then an IgG-anti-tTG may be used (again with a check for deficiency in IgG). But what does it mean, in general, if IgA is low? IgA deficiency (or at least functional deficiency) is a possible explanation, for some of the complications of Celiac Disease, including the development of certain cancers like Non-Hodgkin's Lymphoma. The mechanism would be that a lowered IgA leads to chronic immune insufficiency and erratic immune activation. After a period of time, it could lead to a disordered immune response that looks a lot like autoimmune disease. It's so simple, it's almost simplistic. But we must begin at the beginning, at aflatoxins. This post is long and very dense. If you're not into the sticky deta